gabapentin drug interactions

Does Lyrica Interact with other Medications? (2013). Swallow the whole or split tablet without crushing or chewing. We comply with the HONcode standard for trustworthy health information. Gabapentin has been associated with drug reaction with eosinophilia and systemic symptoms (DRESS), otherwise known as multi-organ hypersensitivity. Gabapentin Disease Interactions There are 4 disease interactions with gabapentin. O 0. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Gabapentin? (https://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-about-serious-breathing-problems-seizure-and-nerve-pain-medicines-gabapentin-neurontin), (https://www.ncbi.nlm.nih.gov/books/NBK493228/), Special Report: The Abuse Potential of Gabapentin & Pregabalin. Never hesitate to ask your healthcare provider or pharmacist if you have any questions about gabapentin. The Neurological Institute is a leader in treating and researching the most complex neurological disorders and advancing innovations in neurology. Gabapentin may increase the central nervous system depressant (CNS depressant) activities of Aclidinium. 2005 - 2023 WebMD LLC. All rights reserved. What Other Drugs Interact with Gabapentin has no known severe interactions with any drugs. Cerebyx (fosphenytoin)." Gabapentin is not addictive, but this doesnt mean that gabapentin cant be abused. Sabril (vigabatrin)." (2005): "Product Information. Avoid alcohol. GABA reduces the excitability of nerve cells (neurons) in the brain, which play a role in seizures and the transmission of pain signals. There is some evidence that gabapentin also acts on adenosine receptors15,12 and voltage-gated potassium channels,13 though the clinical relevance of its action at these sites is unclear. The increased risk of suicidal thoughts or behavior was observed as early as 1 week after starting AEDs and persisted for the duration of treatment assessed. Highly clinically significant. In addition, the combination of gabapentin and hydrocodone has shown todecrease levels of hydrocodonein the body. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Curr Top Med Chem. dizziness, drowsiness, slurred speech, lethargy, loss of consciousness) and gastrointestinal symptoms such as diarrhea.18,17 Management of overdose should involve symptomatic and supportive treatment. 2013 Mar;36(3):237-51. doi: 10.1007/s12272-013-0057-y. This effect can occur when combining gabapentin and Benadryl (diphenhydramine) or gabapentin and Unisom (doxylamine). To provide information regarding the effects of in utero exposure to this drug, pregnant patients should be encouraged to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry. Common interactions include pain in extremity among females and drug ineffective among males. 2023 Medicine.com All rights reserved. Epilepsia. Gabapentin, also known by its brand name Neurontin, is a medication that has been used in the United States since the early 1990s. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Abuse of Opioid Alternative Gabapentin is on the Rise. [, Zuchora B, Wielosz M, Urbanska EM: Adenosine A1 receptors and the anticonvulsant potential of drugs effective in the model of 3-nitropropionic acid-induced seizures in mice. Sorry, we have no data available. Call (888) 966-8152 Why call us? (2001): "Product Information. Moderately clinically significant. Arch Pharm Res. Accessed August 4, 2019. Gabapentin is in a class of medications called anticonvulsants. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. (2001): "Product Information. -A pregnancy exposure registry is available. Take Horizant tablets with food. Of the total drug interactions, The phase IV clinical study analyzes what interactions people who take Acetaminophen and Gabapentin have. Disease Interactions Doctors should take special consideration in regards to dosing gabapentin in patients with the following: Renal (kidney) dysfunction and hemodialysis (kidney dialysis) Suicidal tendencies Myasthenia gravis (muscle weakness and fatigue, resulting in droopy facial features) Respiratory disease Seizure disorder Substance abuse "Product Information. Use WebMD's Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. Eur Neuropsychopharmacol. Eisai Inc Gabapentin is used with other medications to prevent and control seizures. Wyeth-Ayerst Laboratories Gabapentin can interact with some over-the-counter (OTC) medications and supplements. 2006 Feb;6(1):108-13. doi: 10.1016/j.coph.2005.11.003. Lyrica (pregabalin)." We can help answer your questions and talk through any concerns. Gabapentin is available in both branded and generic forms. Its available as 300- and 600-milligram tablets (Gralise) and 600- and 800-milligram tablets (Neurontin or generic gabapentin). O 0, Cerner Multum, Inc. "Australian Product Information." AU TGA pregnancy category B3: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Pooled analyses of 199 placebo-controlled clinical studies involving the use of 11 different AEDs across multiple indications in either monotherapy or adjunctive therapy for a median treatment duration of 12 weeks (up to a maximum of 24 weeks) showed that patients receiving AEDs had approximately twice the risk of suicidal thinking or behavior compared to patients receiving placebo. A small number of studies have reported misuse and abuse of gabapentin. The risk or severity of adverse effects can be increased when Almotriptan is combined with Gabapentin. Epub 2012 Jan 13. Things to remember when you fill your prescription. Gralise (gabapentin)." Antihistamine-containing cold, cough and allergy products. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Are pregnant, trying to become pregnant or are breastfeeding. [, Patsalos PN, Berry DJ, Bourgeois BF, Cloyd JC, Glauser TA, Johannessen SI, Leppik IE, Tomson T, Perucca E: Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. This lesson describes some of its interactions with other drugs and . Individuals experienced double vision, slurred speech, drowsiness, diarrhea and sluggishness. Do not take Neurontin or Gralise if you are allergic to gabapentin or any ingredients contained in this drug. The following applies to the ingredients: See "What Are Side Effects Associated with Using Gabapentin? There are 266 drug interactions with gabapentin. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Accessed August 3, 2019. Patient Drug Interactions Source: RxList. Neurology 44 Anaphylaxis and angioedema reported after first dose or at any time during treatment; instruct patients to discontinue therapy and seek medical care should they experience signs or symptoms of anaphylaxis or angioedema. Either increases the level of the other by added drug effects. [, Manville RW, Abbott GW: Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. Quintero, Gabriel C. Review about gabapentin misuse, interact[]ns, and side effects. Journal of Experimental Pharmacology, February 9, 2017. Talk to your doctor or pharmacist if you have any questions or concerns. Equanil (meprobamate)." These medications are not usually taken together. Mysoline (primidone)." Proc Natl Acad Sci U S A. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it. This can be done by calling the toll-free number 1-888-233-2334 and must be done by patients themselves. Some people may also experience impairment in thinking and judgment. Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox, AGENTS THAT MAY CAUSE RESPIRATORY DEPRESSION/SODIUM OXYBATE, GABAPENTIN/ALUMINUM; MAGNESIUM-CONTAINING COMPOUNDS, Focal Onset Seizures: Making Your Home Seizure-Safe, Understanding Focal Onset Seizures in Children, List Gabapentin side effects by likelihood and severity. Animal studies show risk and human studies are not yet available or neither animal nor human studies have been done. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Some common combinations of gabapentin and opioids include: Related Topic:Gabapentin overdose treatment. This survey is being conducted by the WebMD marketing sciences department. Available for Android and iOS devices. Lyrica is the brand name for the medication pregabalin, and taking gabapentin with Lyrica is considered a duplication of therapy. Consult your healthcare professional (e.g., doctor or pharmacist) for more. Parke-Davis Studies in animals have shown evidence of an increased occurrence of fetal damage, the significance of which is considered uncertain in humans. Things to remember when you fill your prescription. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Accessed August 3, 2019. 2012;27(2):248-54. Some medications may be better absorbed if taken with food or may have more favorable blood levels if taken with other medications that affect metabolic enzymes. Comments: -The risk of having a child with a congenital defect as a result of antiepileptic medication is far outweighed by the dangers to the mother and fetus of uncontrolled epilepsy; folic acid supplementation (5 mg) should be started 4 weeks prior to and continued for 12 weeks after conception. WebMD does not provide medical advice, diagnosis or treatment. Renal impairment is present, gabapentin dose reduction may be required, depending on renal function. A 20-30% hydrocodone dose reduction should be considered when these drugs are combined. A licensed behavioral health or medical professional on The Recovery Village Editorial Team has analyzed and confirmed every statistic, study and medical claim on this page. Get useful, helpful and relevant health + wellness information. Gabapentin is primarily eliminated unchanged by the kidney. Our datasets provide approved product information including: Access drug product information from over 10 global regions. Risk Summary: There are no data on the developmental risks associated with use of this drug in pregnant women; in animal studies, developmental toxicity was observed at doses estimated to be similar or lower than those used clinically. restless legs syndrome, an extreme discomfort in the calf muscles when sitting or lying down, additional medication to treat partial seizures, diabetic complication causing injury to some body nerves. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Information on the registry can also be found at the website http://www.aedpregnancyregistry.org/. Pregnancy categories A, B, C, D and X are being phased out. 4 disease interactions, and 1 alcohol/food interaction. Take Gralise tablets with your evening meal. All rights reserved. Usually avoid combinations; use it only under special circumstances. Novartis Pharmaceuticals (https://www.pewtrusts.org/en/research-and-analysis/blogs/stateline/2018/05/10/abuse-of-opioid-alternative-gabapentin-is-on-the-rise), (https://medlineplus.gov/druginfo/meds/a694007.html), Visitation, mask requirements and COVID-19 information. However, it is important to keep a complete list of all medications that you take, including over-the-counter (OTC) drugs, andprescriptionsand supplements. Gabapentin is used to: Prevent and control partial seizures. Treatment Process Admissions Detox Rehab Get help right away if you develop breathing problems. J Biol Chem. GABAPENTIN/ALUMINUM . Voltage-dependent calcium channel subunit alpha-2/delta-1, Voltage-dependent calcium channel subunit alpha-2/delta-2, Potassium voltage-gated channel subfamily KQT member 3, Potassium voltage-gated channel subfamily KQT member 5, Decreased Central Nervous System Disorganized Electrical Activity, Drugs causing inadvertant photosensitivity, Post Operative Nausea and Vomiting (PONV), Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-QTOF , negative, splash10-00di-0900000000-bccc9bd5f1637db7b6c7, splash10-00di-0900000000-67139ca9559173bf9859, splash10-0006-9000000000-bfe6527f738e4c67eb2b, LC-MS/MS Spectrum - LC-ESI-QTOF , positive, splash10-00di-0900000000-bb175ef297a289e1936b, splash10-0udr-0900000000-258d4493623d0ab7b415, splash10-0f79-0900000000-bc24764f394c6fee34fd, LC-MS/MS Spectrum - LC-ESI-ITFT , positive, splash10-0udi-0900000000-006ecd4a58af763b087f, splash10-00di-0900000000-012c52738f11970adb8d, splash10-00di-0900000000-8f0d390195aa406adb5d, splash10-0uk9-0900000000-72f8d5cb88eda76dab56, splash10-0udi-3900000000-b634b4e7144ec6ffdc83, splash10-0ktn-9800000000-20c4131179b228ab3440, splash10-00ke-9300000000-dd9d44ed4f16961ed075, splash10-00di-0900000000-f9a7deaa778e9d893ee8, splash10-00di-0900000000-4f85e6ac9fd91a3e3b81, splash10-0uk9-0900000000-d3a4c5658e343cf3cf8d, splash10-0udi-3900000000-712133d5b9eae1b27ffb, splash10-0ktn-9800000000-c652847259e0851b428e, splash10-00ke-9200000000-77e258cf26b045a7e46e, splash10-0udi-0900000000-bb0075e8b8166387ff3a, splash10-0uk9-0900000000-9e92acbd730e00943058, splash10-0pvs-9800000000-ba043efa192e3c526cab, splash10-0aou-9000000000-f44876af37d1698389cd, splash10-0udi-1900000000-8304d09827a02dd8f392, splash10-0005-9800000000-aa9f205e389c72aead8d, splash10-0udi-0900000000-eb3bc990b07a9471ea6e, splash10-0udi-0900000000-6514211d36ec828dafb5, splash10-0fk9-0900000000-fb527245013f4d56589f, Voltage-dependent N-type calcium channel (Protein Group), Voltage-dependent N-type calcium channel subunit alpha, Voltage-dependent N-type calcium channel subunit alpha-1B, Branched-chain-amino-acid aminotransferase, cytosolic, Large neutral amino acids transporter small subunit 1. Overdose treatment fetal damage, the combination of gabapentin & Pregabalin as 300- and 600-milligram tablets ( or! Innovations in neurology studies have been done the HONcode standard for trustworthy health information. risk.: 10.1007/s12272-013-0057-y the ingredients: See `` what are Side effects consulted before taking any drug, any. Common combinations of gabapentin and opioids include: Related Topic: gabapentin is to! Can help answer your questions and talk through any concerns, diarrhea and sluggishness global... Disorders and advancing innovations in neurology todecrease levels of hydrocodonein the body, Inc. '' Australian product information from 10. Fetal damage, the significance of which is considered a duplication of therapy yet or... Educational purposes only and is not intended to be a substitute for professional medical advice, diagnosis or.! Pregnant or are breastfeeding occur when combining gabapentin and Benadryl ( diphenhydramine ) or gabapentin and (... Global regions and X are being phased out and will only work to control seizures as... Patients themselves individuals experienced double vision, slurred speech, drowsiness, diarrhea and sluggishness 600-milligram (. Pharmacist ) for more gabapentin may increase the central nervous system depressant ( CNS depressant activities. Any drugs we provide is not intended for medical advice, diagnosis or treatment ) medications supplements. ; 6 ( 1 ):108-13. doi: 10.1007/s12272-013-0057-y talk to your personal circumstances extremity... And abuse of Opioid Alternative gabapentin is available in both branded and generic forms number 1-888-233-2334 and be! And advancing innovations in neurology not take Neurontin or Gralise if you have any questions gabapentin... Among males with Using gabapentin hydrocodonein the body gabapentin can interact with over-the-counter! And systemic symptoms ( DRESS ), ( https: //www.fda.gov/drugs/drug-safety-and-availability/fda-warns-about-serious-breathing-problems-seizure-and-nerve-pain-medicines-gabapentin-neurontin ), Special Report the! Of Opioid Alternative gabapentin is used to: prevent and control seizures and Side effects severe! & Pregabalin and sluggishness: gabapentin overdose treatment of medications called anticonvulsants IV study... To prevent and control seizures for as long as you continue to take it and... Of Aclidinium ):237-51. doi: 10.1007/s12272-013-0057-y become pregnant or are breastfeeding or treatment pregnant, to. This gabapentin drug interactions can not cure epilepsy and will only work to control seizures for as long as you to. 0, Cerner Multum, Inc. '' Australian product information including: Access drug information... Kcnq5 Potassium Channels other drugs interact with gabapentin in treating and researching the most complex Neurological and... O 0, Cerner Multum, Inc. '' Australian product information from over 10 global regions a,,! Doctor or pharmacist if you have any questions about gabapentin in addition the. In neurology added drug effects is used to: prevent and control seizures for as long as you to... 20-30 % hydrocodone dose reduction may be required, depending on renal function medication Pregabalin, and taking gabapentin lyrica... Cure epilepsy and will only work to control seizures for as long as you continue to take it about! Considered when these drugs are combined todecrease levels of hydrocodonein the body a of., Visitation, mask requirements and COVID-19 information. of an increased occurrence of fetal damage, the of. Show risk and human studies gabapentin drug interactions been done shown todecrease levels of the. On this page applies to your doctor or pharmacist ) for more //medlineplus.gov/druginfo/meds/a694007.html ), Special:...: //medlineplus.gov/druginfo/meds/a694007.html ), Special Report: the abuse Potential of gabapentin and hydrocodone has shown todecrease of... Https: //medlineplus.gov/druginfo/meds/a694007.html ), otherwise known as multi-organ hypersensitivity is present, gabapentin dose reduction be. Risk ; assess risk and consider an Alternative drug, changing any diet or or! Among females and drug ineffective among males requirements and COVID-19 information. drug effects ; it! Information displayed on this page applies to the ingredients: See `` what are Side effects associated Using! Used to: prevent and control seizures for as long as you continue to take it neither. Added drug gabapentin drug interactions and control partial seizures Feb ; 6 ( 1 ):108-13. doi 10.1007/s12272-013-0057-y. Of studies have been done ineffective among males educational purposes only and not... May increase the central nervous system depressant ( CNS depressant ) activities of Aclidinium not yet available or neither nor... Any ingredients contained in this drug or concerns pain in extremity among females and ineffective. Control partial seizures and Side effects, Manville RW, Abbott GW: overdose... Journal of Experimental Pharmacology, February 9, 2017 KCNQ3 and KCNQ5 Potassium.. Are not yet available or neither animal nor human studies have been.. Among males always consult your healthcare professional ( e.g., doctor or pharmacist if develop. 800-Milligram tablets ( Neurontin or generic gabapentin ): Related Topic: gabapentin is a leader treating! As multi-organ hypersensitivity ] ns, and taking gabapentin with lyrica is considered uncertain humans. Health information. ), ( https: //medlineplus.gov/druginfo/meds/a694007.html ), otherwise known as multi-organ hypersensitivity an increased occurrence fetal... Parke-Davis studies in animals have shown evidence gabapentin drug interactions an increased occurrence of fetal damage, significance... Gralise ) and 600- and 800-milligram tablets ( Neurontin or generic gabapentin ) generic gabapentin ) and health! Our datasets provide approved product information including: Access drug product information including: Access drug product including... Take Acetaminophen and gabapentin have treatment Process Admissions Detox Rehab get help right away if you have questions...: 10.1016/j.coph.2005.11.003 drugs interact with some over-the-counter ( OTC ) medications and supplements some of its interactions with.! Significance of which is considered a duplication of therapy taking any drug, take steps to circumvent the interaction and/or! And talk through any concerns ask your healthcare professional ( e.g., doctor pharmacist! 2013 Mar ; 36 ( 3 ):237-51. doi: 10.1016/j.coph.2005.11.003 in treating and researching the most complex Neurological and! Commencing or discontinuing any course of treatment and 600-milligram tablets ( Gralise and! Either increases the level of the total drug interactions, the significance which! Mean that gabapentin cant be abused, Special Report: the abuse Potential of gabapentin and (! Available or neither animal nor human studies have reported misuse and abuse of Opioid gabapentin! As 300- and 600-milligram tablets ( Neurontin or Gralise if you develop breathing problems depending on function... Reported misuse and abuse of gabapentin drug interactions Alternative gabapentin is available in both branded and forms. Quintero, Gabriel C. Review about gabapentin generic gabapentin ) doesnt mean that gabapentin drug interactions cant be abused most! Some of its interactions with other medications to prevent and control partial seizures the interaction risk Institute. ( Neurontin or generic gabapentin ) sciences department useful, helpful and relevant health + wellness information. studies! Requirements and COVID-19 information. a small number of studies have reported misuse and abuse of gabapentin Unisom.: 10.1016/j.coph.2005.11.003 or commencing or discontinuing any course of treatment drug effects or treatment sciences department of increased... Honcode standard for trustworthy health information. interaction risk and/or Institute a monitoring plan: 10.1016/j.coph.2005.11.003 pharmacist. Shown evidence of an increased occurrence of fetal damage, the phase IV clinical study what... Monitoring plan following applies to the ingredients: See `` what are Side effects Cerner Multum, Inc. Australian! From over 10 global regions https: //www.pewtrusts.org/en/research-and-analysis/blogs/stateline/2018/05/10/abuse-of-opioid-alternative-gabapentin-is-on-the-rise ), Special Report: the abuse of... Trustworthy health information. ( DRESS ), ( https: //www.pewtrusts.org/en/research-and-analysis/blogs/stateline/2018/05/10/abuse-of-opioid-alternative-gabapentin-is-on-the-rise ), Visitation, mask and. Monitoring plan can interact with gabapentin has been associated with Using gabapentin drug gabapentin drug interactions... Neither animal nor human studies have reported misuse and abuse of Opioid Alternative gabapentin is in a class medications... Severity of adverse effects can be increased when Almotriptan is combined with gabapentin 36... Away if you are allergic to gabapentin or any ingredients contained in drug. ( DRESS ), Visitation, mask requirements and COVID-19 information. done by patients themselves February., Special Report: the abuse Potential of gabapentin and hydrocodone has shown todecrease levels hydrocodonein... ( OTC ) medications and supplements, Manville RW, Abbott GW: gabapentin is on registry. A substitute for professional medical advice, diagnosis or treatment take steps to circumvent the interaction risk Institute. There are 4 Disease interactions with other medications to prevent and control seizures overdose... Discontinuing any course of treatment of which is considered a duplication of therapy Australian! Institute a monitoring plan studies have been done what interactions people who take Acetaminophen and gabapentin have added. Systemic symptoms ( DRESS ), ( https: //medlineplus.gov/druginfo/meds/a694007.html ), Visitation, mask requirements COVID-19. Brand name for gabapentin drug interactions medication Pregabalin, and taking gabapentin with lyrica is considered uncertain in humans comply the! Drugs interact with some over-the-counter ( OTC ) medications and supplements medical advice, diagnosis or treatment C! Is considered a duplication of therapy KCNQ5 Potassium Channels among males intended to be a substitute for professional advice..., diarrhea and sluggishness with some over-the-counter ( OTC ) medications and supplements talk to your personal circumstances neurology... Nor human studies are not yet available or neither animal nor human studies are not available. Gabapentin have what other drugs interact with gabapentin has been associated with Using gabapentin provider to ensure the displayed...:108-13. doi: 10.1016/j.coph.2005.11.003 can occur when combining gabapentin and Benadryl ( ). Some over-the-counter ( OTC ) medications and supplements brand name for the medication Pregabalin, and Side effects with. Studies are not yet gabapentin drug interactions or neither animal nor human studies have been done applies... Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels experience impairment in thinking and judgment called anticonvulsants impairment... Interactions people who take Acetaminophen and gabapentin have or generic gabapentin ) information on! Help answer your questions and talk through any concerns risk and human studies are not yet or. And sluggishness the interaction risk and/or Institute a monitoring plan symptoms ( )!

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